Type

Journal Article

Authors

Emmanuel Roze
Bertrand Gaymard
Marie Vidailhet
Eavan McGovern
Billy François
Alexis Demas
Sylvie Mécharles
Mireille Edimo Nana Kaptué
Véronique Pelonde
Benoit Tressières
and 3 others

Subjects

Environment

Topics
high frequency environmental exposure educational level cluster risk factor community based french west

Further evidence for a distinctive atypical degenerative parkinsonism in the Caribbean: A new cluster in the French West Indian Island of Martinique. (2017)

Abstract A high prevalence of an atypical levodopa-resistant parkinsonism has been reported in the Caribbean island of Guadeloupe. These seminal observations have not been replicated or extended to neighbouring populations who share genetic and environmental characteristics. To further characterise this atypical parkinsonism we prospectively investigated 305 consecutive patients with neurodegenerative parkinsonism in a community-based population from Guadeloupe and Martinique, a neighbouring French Caribbean island where the population has similar environmental and genetic backgrounds. The aims of this study were to confirm the frequency of atypical parkinsonism within this cohort and to precisely define its clinical phenotype. A high frequency (66%) of atypical parkinsonism was identified in both Guadeloupe and Martinique. The clinical phenotype consisted of a levodopa-resistant parkinsonism with postural instability (72%), early dementia (58%), dysautonomia (58%), rapid-eye-movement sleep behavioural disorder (53%), hallucinations (43%), and supranuclear gaze palsy (29%). A low educational level was identified as a major risk factor for developing atypical parkinsonism (p < .001). Our findings support the existence of a distinctive atypical parkinsonism - Caribbean Parkinsonism - within the French Caribbean Islands. This could either correspond to a single entity or reflect a propensity for developing more widespread and rapidly progressive lesions in Caribbean patients with parkinsonism. In both cases, genetic susceptibility and/or environmental exposure may be involved.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Emmanuel Roze, Bertrand Gaymard, Marie Vidailhet, Eavan McGovern, Billy François, Alexis Demas, Sylvie Mécharles, Mireille Edimo Nana Kaptué, Véronique Pelonde, Benoit Tressières and 3 others

Experts in our system

1
Eavan M McGovern
University College Dublin
Total Publications: 12