Journal Article


Michael Kerr
Christine Linehan
Robert Potter
Ann John
Fabiola Fernandez-Gutierrez
Jonathan Kennedy
Sinead Brophy



cohort study data analysis intellectual disabilities logistic regression hospital records respiratory disease general practice descriptive statistics

Characteristics of Children Prescribed Antipsychotics: Analysis of Routinely Collected Data. (2018)

Abstract Antipsychotics are licensed for psychosis and are also prescribed for behavior control. This study aims to examine characteristics and outcomes of children prescribed antipsychotics. A cohort study using general practice and hospital records linked with education records for 1,488,936 children living in Wales between 1999 and 2015. The characteristics of the children who were prescribed antipsychotics are presented using descriptive statistics and outcomes such as respiratory illness, diabetes, and injury were analyzed using multilevel logistic regression and the prior event rate ratio (PERR). Children with intellectual difficulty/autism were more likely to be prescribed antipsychotics (2.8% have been prescribed an antipsychotic [75% with autism] compared with 0.15% of children without intellectual difficulty). Those with intellectual disabilities/autism were prescribed antipsychotics at a younger age and for a longer period. Antipsychotic use was associated with a higher rate of respiratory illness for all (PERR of hospital admission: 1.55 [95% CI: 1.51-1.598] or increase in rate of 2 per 100 per year in those treated), and for those with intellectual difficulty/autism, there was a higher rate of injury and hospitalized depression. However, among those without intellectual difficulty/autism, there were lower rates of depression (PERR: 0.55 [95% CI: 0.51-0.59]). This work shows real-world use of antipsychotics and provides information on the rate of possible adverse events in children treated. Antipsychotics are predominantly used for those with intellectual difficulty/autism rather than those with a psychotic diagnosis. There is evidence that rates of respiratory disease, epilepsy, and diabetes are also higher postantipsychotic use for all. In those with intellectual difficulty/autism, hospital-admitted depression and injury are higher postantipsychotic use. The use of antipsychotics for behavioral management is likely to have increased cost implications to the healthcare system.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Michael Kerr, Christine Linehan, Robert Potter, Ann John, Fabiola Fernandez-Gutierrez, Jonathan Kennedy, Sinead Brophy

Experts in our system

Jonathan Kennedy
University College Cork
Total Publications: 31