Type

Journal Article

Authors

Fionnuala M McAuliffe
Mensud Hatunic
Michael E Foley
Thomas P Smith
Mary Coffey
Sinéad Curran
Maria A Kennelly
Lorraine Brennan
Karen L Lindsay

Subjects

Veterinary

Topics
high rate glucose tolerance test body mass index gestational diabetes mellitus insulin resistance treatment response diabetes treatment blood glucose

Maternal metabolic response to dietary treatment for impaired glucose tolerance and gestational diabetes mellitus. (2017)

Abstract Dietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary therapies and the optimal dietary approach remains uncertain. To assess changes in maternal glycemic profile and pregnancy outcomes among women with diet-controlled IGT and GDM. Pregnant women who had one or more elevated values on a 3-h oral glucose tolerance test were enrolled. All participants received dietary advice and glucose monitoring as part of routine clinical care. Fasting and 1-h post-prandial blood samples, collected prior to initiation of clinical treatment and repeated 4-6 weeks later, were analyzed for glucose, insulin, and C-peptide. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Women who required pharmacological therapy for glucose control were excluded from analyses. Participants (N = 93) were of moderately older age (mean 33 years), with a high rate of overweight/obesity (mean body mass index (BMI) = 28.65 kg/m Although improvements in blood glucose levels were observed among women with diet-controlled IGT and GDM, this was insufficient to significantly affect insulin resistance or perinatal outcome. Late diagnosis and treatment of IGT/GDM may have contributed to such outcomes.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Fionnuala M McAuliffe, Mensud Hatunic, Michael E Foley, Thomas P Smith, Mary Coffey, Sinéad Curran, Maria A Kennelly, Lorraine Brennan, Karen L Lindsay

Experts in our system

1
Fionnuala M McAuliffe
University College Dublin
Total Publications: 176
 
2
Mensud Hatunic
University College Dublin
Total Publications: 6
 
3
Michael E Foley
University College Dublin
Total Publications: 25
 
4
Thomas Smith
University College Cork
Total Publications: 5
 
5
Mary Coffey
Trinity College Dublin
Total Publications: 21
 
6
Maria A Kennelly
University College Cork
 
7
Lorraine Brennan
University College Dublin
Total Publications: 166
 
8
Karen L Lindsay
University College Dublin
Total Publications: 19