Journal Article


M C M de Jong
G McGrath
J. O'Keeffe
S J More
K Frankena
I Aznar



generalized model novel the statistical analysis transmission analytical methods quantification mycobacterium bovis trial

Quantification of Mycobacterium bovis transmission in a badger vaccine field trial. (2017)

Abstract In the UK and Ireland, Bacille Calmette-Guérin (BCG) vaccination of badgers has been suggested as one of a number of strategies to control or even eradicate Mycobacterium bovis infection in badgers. In this manuscript, we present the results of a badger field trial conducted in Ireland and discuss how the novel trial design and analytical methods allowed the effects of vaccination on protection against infection and, more importantly, on transmission to be estimated. The trial area was divided into three zones North to South (A, B and C) where vaccination coverages of 0, 50 and 100%, respectively, were applied. Badgers were trapped over a 4year period. Badgers were assigned to either placebo or vaccine treatment, with treatment allocation occurring randomly in zone B. Blood samples were collected at each capture, and serology was performed in these samples using a chemiluminescent multiplex ELISA system (Enfer test). The analysis aimed to compare new infections occurring in non-infected non-vaccinated badgers to those in non-infected vaccinated ones, while accounting for the zone in which the badger was trapped and the infection pressure to which this individual badger was exposed. In total, 440 records on subsequent trappings of individual non-infected badgers were available for analysis. Over the study period, 55 new infections occurred in non-vaccinated (out of 239=23.0%) and 40 in vaccinated (out of 201=19.9%) badgers. A Generalized Linear Model (GLM) with a cloglog link function was used for analysis. Statistical analysis showed that susceptibility to natural exposure with M. bovis was reduced in vaccinated compared to placebo treated badgers: vaccine efficacy for susceptibility, VE
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

M C M de Jong, G McGrath, J. O'Keeffe, S J More, K Frankena, I Aznar

Experts in our system

Guy McGrath
University College Dublin
Total Publications: 52
James O'Keeffe
University College Dublin
Total Publications: 48
S J More
University College Dublin
Total Publications: 213
Klaas Frankena
University College Dublin
Total Publications: 8
I Aznar
University College Dublin
Total Publications: 10