Journal Article


Stephen V. Gordon
Kerri M. Malone



classification genetic markers mycobacterium caniformia mycobacterium bovis phylogeny animals wild epidemiology goats mycobacterium infections animals domestic humans species specificity transmission cattle mycobacterium tuberculosis rodentia animals host specificity genome bacterial genetics microbiology

Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals. (2017)

Abstract The Mycobacterium tuberculosis complex (MTBC) is composed of several highly genetically related species that can be broadly classified into those that are human-host adapted and those that possess the ability to propagate and transmit in a variety of wild and domesticated animals. Since the initial description of the bovine tubercle bacillus, now known as Mycobacterium bovis, by Theobald Smith in the late 1800's, isolates originating from a wide range of animal hosts have been identified and characterized as M. microti, M. pinnipedii, the Dassie bacillus, M. mungi, M. caprae, M. orygis and M. suricattae. This chapter outlines the events resulting in the identification of each of these animal-adapted species, their close genetic relationships, and how genome-based phylogenetic analyses of species-specific variation amongst MTBC members is beginning to unravel the events that resulted in the evolution of the MTBC and the observed host tropism between the human- and animal-adapted member species.
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Full list of authors on original publication

Stephen V. Gordon, Kerri M. Malone

Experts in our system

Stephen V. Gordon
University College Dublin
Total Publications: 40
Kerri M. Malone
University College Dublin
Total Publications: 9