Type

Journal Article

Authors

Heather J Cordell
David E Barton
Rajko B Kenda
Adrian S Woolf
Prem Puri
Timothy H J Goodship
John A Sayer
Mauro Santibanez-Koref
Andrew J Green
Heather J Lambert
and 9 others

Subjects

Psychiatry

Topics
genetic linkage reflux urinary tract case control region genome wide association study genetic association primary

Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. (2017)

Abstract Vesicoureteric reflux (VUR) is the commonest urological anomaly in children. Despite treatment improvements, associated renal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hypertension and renal failure. Primary VUR is familial, with transmission rate and sibling risk both approaching 50%, and appears highly genetically heterogeneous. It is often associated with other developmental anomalies of the urinary tract, emphasising its etiology as a disorder of urogenital tract development. We conducted a genome-wide linkage and association study in three European populations to search for loci predisposing to VUR. Family-based association analysis of 1098 parent-affected-child trios and case/control association analysis of 1147 cases and 3789 controls did not reveal any compelling associations, but parametric linkage analysis of 460 families (1062 affected individuals) under a dominant model identified a single region, on 10q26, that showed strong linkage (HLOD = 4.90; ZLRLOD = 4.39) to VUR. The ~9Mb region contains 69 genes, including some good biological candidates. Resequencing this region in selected individuals did not clearly implicate any gene but FOXI2, FANK1 and GLRX3 remain candidates for further investigation. This, the largest genetic study of VUR to date, highlights the 10q26 region as a major genetic contributor to VUR in European populations.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Heather J Cordell, David E Barton, Rajko B Kenda, Adrian S Woolf, Prem Puri, Timothy H J Goodship, John A Sayer, Mauro Santibanez-Koref, Andrew J Green, Heather J Lambert and 9 others

Experts in our system

1
David E. Barton
University College Dublin
Total Publications: 19
 
2
Prem Puri
University College Dublin
Total Publications: 117
 
3
Timothy H J Goodship
University College Dublin
Total Publications: 4
 
4
Andrew Green
University College Dublin
Total Publications: 25