Type

Journal Article

Authors

Lorraine Brennan
Eileen R Gibney
Michael J Gibney
John C Mathers
Julie A Lovegrove
Wim H M Saris
J Alfredo Martinez
Yannis Manios
Hannelore Daniel
Christian A Drevon
and 18 others

Subjects

Medicine & Nursing

Topics
precision medicine health education metabolome cluster analysis administration dosage linear models female body mass index healthy diet nutrition policy male nutritional status blood fatty acids omega 3 cholesterol middle aged carotenoids young adult humans european continental ancestry group adult

Metabotyping for the development of tailored dietary advice solutions in a European population: the Food4Me study. (2017)

Abstract Traditionally, personalised nutrition was delivered at an individual level. However, the concept of delivering tailored dietary advice at a group level through the identification of metabotypes or groups of metabolically similar individuals has emerged. Although this approach to personalised nutrition looks promising, further work is needed to examine this concept across a wider population group. Therefore, the objectives of this study are to: (1) identify metabotypes in a European population and (2) develop targeted dietary advice solutions for these metabotypes. Using data from the Food4Me study (n 1607), k-means cluster analysis revealed the presence of three metabolically distinct clusters based on twenty-seven metabolic markers including cholesterol, individual fatty acids and carotenoids. Cluster 2 was identified as a metabolically healthy metabotype as these individuals had the highest Omega-3 Index (6·56 (sd 1·29) %), carotenoids (2·15 (sd 0·71) µm) and lowest total saturated fat levels. On the basis of its fatty acid profile, cluster 1 was characterised as a metabolically unhealthy cluster. Targeted dietary advice solutions were developed per cluster using a decision tree approach. Testing of the approach was performed by comparison with the personalised dietary advice, delivered by nutritionists to Food4Me study participants (n 180). Excellent agreement was observed between the targeted and individualised approaches with an average match of 82 % at the level of delivery of the same dietary message. Future work should ascertain whether this proposed method could be utilised in a healthcare setting, for the rapid and efficient delivery of tailored dietary advice solutions.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Lorraine Brennan, Eileen R Gibney, Michael J Gibney, John C Mathers, Julie A Lovegrove, Wim H M Saris, J Alfredo Martinez, Yannis Manios, Hannelore Daniel, Christian A Drevon and 18 others

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Eileen R Gibney
University College Dublin
Total Publications: 98
 
3
Michael J Gibney
University College Dublin
Total Publications: 102
 
4
John C Mathers
University College Dublin
Total Publications: 33
 
5
Julie A Lovegrove
University College Dublin
Total Publications: 46
 
6
Wim H M Saris
University College Dublin
Total Publications: 39
 
7
J Alfredo Martinez
University College Dublin
Total Publications: 32
 
8
Yannis Manios
University College Dublin
Total Publications: 38
 
9
Hannelore Daniel
University College Dublin
Total Publications: 33
 
10
Christian A Drevon
University College Dublin
Total Publications: 39