Type

Journal Article

Authors

Helen M Roche
Peadar O'Gaora
Lorraine Brennan
Miriam Ryan
Colm O'Grada
Aoife M Murphy
Anna Weiser
Ruth M Connaughton
Attia Fatima

Subjects

Biochemistry

Topics
network analysis lipid a inflammation gene expression cholesterol metabolism g protein coupled receptor lipid metabolism energy metabolism

Weighted Gene Co-Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge. (2017)

Abstract Inflammation is characteristic of diet-related diseases including obesity and type 2 diabetes (T2D). However, biomarkers of inflammation that reflect the early stage metabolic derangements are not optimally sensitive. Lipid challenges elicit postprandial inflammatory and metabolic responses. Gender-specific transcriptomic networks of the peripheral blood mononuclear cell (PBMC) were constructed in response to a lipid challenge. Eighty-six adult males and females of comparable age, anthropometric, and biochemical profiles completed an oral lipid tolerance test (OLTT). PBMC transcriptome was profiled following OLTT. Weighted gene coexpression networks were constructed separately for males and females. Functional ontology analysis of network modules was performed and hub genes identified. Two modules of interest were identified in females-an "inflammatory" module and an "energy metabolism" module. NLRP3, which plays a central role in inflammation and STARD3 that is involved in cholesterol metabolism, were identified as hub genes for the respective modules. The OLTT induced some gender-specific correlations of gene coexpression network modules. In females, biological processes relating to energy metabolism and inflammation pathways were evident. This suggests a gender specific link between inflammation and energy metabolism in response to lipids. In contrast, G-protein coupled receptor protein signaling pathway was common to both genders.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M Roche, Peadar O'Gaora, Lorraine Brennan, Miriam Ryan, Colm O'Grada, Aoife M Murphy, Anna Weiser, Ruth M Connaughton, Attia Fatima

Experts in our system

1
Helen M. Roche
University College Dublin
Total Publications: 105
 
2
Peadar O'Gaora
University College Dublin
Total Publications: 11
 
3
Lorraine Brennan
University College Dublin
Total Publications: 166
 
4
Miriam Ryan
University College Dublin
Total Publications: 34
 
5
Aoife M Murphy
University College Dublin
Total Publications: 3
 
6
Ruth M Connaughton
University College Dublin
Total Publications: 6