Type

PhD Thesis

Authors

Francis Finucane

Subjects

Physiotherapy & Sport

Topics
public health irish people insulin resistance irish type clinical medicine m d m d trinity college dublin young people body mass index

Obesity, insulin resistance and Type 2 Diabetes in young Irish people (2008)

Abstract The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I performed a retrospective observational study of a clinic based cohort of obese Irish children. Analysis of data relating to age, body mass index and blood pressure showed that younger patients tended to have a higher degree of obesity at initial presentation, while half of the cohort had initial blood pressure measurements in the hypertensive range. There was a correlation between the degree of obesity and blood pressure elevation. In a smaller, prospective follow up study from this cohort, more detailed physiological characterisation showed that there were significant correlations between the degree of obesity and insulin resistance, dyslipidaemia and suspected fatty liver disease. Subsequently, I conducted detailed metabolic assessments of young obese people with type 2 diabetes and demonstrated marked defects in beta-cell function in addition to severe insulin resistance. Somewhat surprisingly, these parameters did not improve after twelve weeks of fully supervised aerobic exercise.
Collections Ireland -> Trinity College Dublin -> Clinical Medicine (Theses and Dissertations)
Ireland -> Trinity College Dublin -> Clinical Medicine
Ireland -> Trinity College Dublin -> Trinity College Dublin Theses & Dissertations
Ireland -> Trinity College Dublin -> Trinity College Dublin, the University of Dublin: Theses & Dissertations
Ireland -> Trinity College Dublin -> School of Medicine

Full list of authors on original publication

Francis Finucane

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