Type

Journal Article

Authors

John Reynolds
Narayanasamy Ravi
Julia Mary Howard
Claire Donohoe
Rory Casey
Joanne Lysaght
Graham Pidgeon
Emma Allott

Subjects

Pharmacology

Topics
obesity vacm subcutaneous tissue cell proliferation oncology il 6 visceral adipose tissue conditioned media pro inflammatory

Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue (2011)

Abstract Obesity has been associated with increased incidence and mortality of oesophageal and colorectal adenocarcinoma. Excess central adiposity may drive this association through an altered inflammatory milieu. Utilizing a unique adipose tissue bioresource we aimed to determine the pro-tumour properties of visceral adipose tissue. Comparing subcutaneous and visceral adipose tissue depots, we observed significantly higher levels of VEGF and IL-6, along with significantly higher proportions of CD8+ T cells and NKT cells in visceral adipose tissue. Significantly higher levels of VEGF were observed in the conditioned media from visceral adipose tissue of centrally obese compared to non-obese patients. We also report a significant increase in oesophageal and colorectal tumour cell proliferation following culture with conditioned media from visceral adipose tissue of centrally obese patients. Neutralizing VEGF in the conditioned media significantly decreased tumour cell proliferation. This novel report highlights a potential mechanism whereby visceral adipose tissue from centrally obese cancer patients may drive tumour progression.
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Full list of authors on original publication

John Reynolds, Narayanasamy Ravi, Julia Mary Howard, Claire Donohoe, Rory Casey, Joanne Lysaght, Graham Pidgeon, Emma Allott

Experts in our system

1
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
2
N Ravi
Trinity College Dublin
Total Publications: 61
 
3
Claire L Donohoe
Trinity College Dublin
Total Publications: 38
 
4
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
5
Graham Pidgeon
Trinity College Dublin
Total Publications: 38