Type

Journal Article

Authors

Kenneth A Dawson
Ester Polo
Fabian Meder
Maria Cristina Lo Giudice
Luca Boselli
W Zhao
Jonathan Coleman
Valentina Castagnola

Subjects

Psychiatry

Topics
apolipoprotein a i biomaterials proteins lipoprotein nanoparticle biological interactions graphene nanoflakes biological graphene systematic study nanoparticles recognition

Biological recognition of graphene nanoflakes (2018)

Abstract The systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. Here, we develop a biocompatible long-term colloidally stable water dispersion of few-layered graphene nanoflakes in the biological exposure medium in which it will be studied. We also report the study of the orientation and functionality of key proteins of interest in the biolayer (corona) that are believed to mediate most of the early biological interactions. The evidence accumulated shows that graphene nanoflakes are rich in effective apolipoprotein A-I presentation, and we are able to map specific functional epitopes located in the C-terminal portion that are known to mediate the binding of high-density lipoprotein to binding sites in receptors that are abundant in the liver. This could suggest a way of connecting the materials' properties to the biological outcomes.
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Full list of authors on original publication

Kenneth A Dawson, Ester Polo, Fabian Meder, Maria Cristina Lo Giudice, Luca Boselli, W Zhao, Jonathan Coleman, Valentina Castagnola

Experts in our system

1
Kenneth A. Dawson
University College Dublin
Total Publications: 152
 
2
Ester Polo
University College Dublin
Total Publications: 12
 
3
Fabian Meder
University College Dublin
Total Publications: 6
 
4
Maria Cristina Lo Giudice
University College Dublin
Total Publications: 5
 
5
Luca Boselli
University College Dublin
Total Publications: 6
 
6
Wenhui Zhao
University of Limerick
Total Publications: 10
 
7
Jonathan Coleman
Trinity College Dublin
Total Publications: 217
 
8
Valentina Castagnola
University College Dublin
Total Publications: 7