Type

Journal Article

Authors

Luke O'Neill
Melissa J Conroy
Joanne Lysaght
Mary B Mockler

Subjects

Microbiology

Topics
immune system cancer targeting metabolic targeting agents immunometabolism t cell tumor microenvironment cancer this review immunology inflammation infection global health t cells obesity cancer cell

Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. (2014)

Abstract The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Naïve T cells predominantly require an ATP generating metabolic profile, whereas proliferating effector T cells require anabolic metabolic profiles that promote rapid growth and proliferation. Furthermore, specific T cell subsets require distinct energetic and biosynthetic pathways to match their functional requirements. The often hostile tumor microenvironment can affect T cell immune responses by altering the resulting cellular metabolism. Tailoring immune responses by manipulating cellular metabolic pathways may provide an exciting new option for cancer immunotherapy. T cell responses might also be skewed via metabolic manipulation to treat the complications of obesity-associated inflammation, which is a rapidly growing global health problem and a major risk factor for many malignancies. In this review, the diverse metabolic requirements of T cells in anti-tumor immunity are discussed, as well as the profound influence of the tumor microenvironment and the possible avenues for manipulation to enhance anti-tumor immunity.
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Full list of authors on original publication

Luke O'Neill, Melissa J Conroy, Joanne Lysaght, Mary B Mockler

Experts in our system

1
Luke Anthony John O'Neill
Trinity College Dublin
Total Publications: 262
 
2
Melissa J Conroy
Trinity College Dublin
Total Publications: 14
 
3
Joanne Lysaght
Trinity College Dublin
Total Publications: 39