Type

Journal Article

Authors

Marina Lynch
Ian H Robertson
Brian A. Lawlor
Sabina Brennan
Liam Barry Carroll
Michael O'Sullivan
Caoimhe Hannigan
Hannah Wolfe

Subjects

Psychology

Topics
memory kinase 2 adult psychology blood cells cognitive psychology individuals glycolysis

A shift to glycolysis accompanies the inflammatory changes in PBMCs from individuals with an IQ-discrepant memory (2018)

Abstract Identification of a blood-based biomarker that can detect early cognitive decline presents a significant healthcare challenge. We prepared peripheral blood mononuclear cells (PBMCs) from individuals who had a poorer than predicted performance in their delayed recall performance on the Logical Memory II Subtest of the Wechsler Memory Scale (WMS) relative to their IQ estimated by the National Adult Reading Test (NART); we described these individuals as IQ-discrepant, compared with IQ-consistent, individuals. Stimulation with Aβ + LPS increased production of TNFα to a greater extent in cells from IQ-discrepant, compared with IQ-consistent, individuals. This was associated with a shift towards glycolysis and the evidence indicates that 6-phosphofructo-2 kinase/fructose-2,6-biphosphatase (PFKFB)3 plays a role in driving glycolysis. A similar shift towards glycolysis was observed in MDMs prepared from IQ-discrepant, compared with IQ-consistent, individuals. The important finding here is that we have established an increased sensitivity to Aβ + LPS stimulation in PBMCs from individuals that under-perform on a memory task, relative to their estimated premorbid IQ, which may be an indicator of early cognitive decline. This may be a useful tool in determining the presence of early cognitive dysfunction.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognitive psychology
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College Ireland -> Type = Article
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology

Full list of authors on original publication

Marina Lynch, Ian H Robertson, Brian A. Lawlor, Sabina Brennan, Liam Barry Carroll, Michael O'Sullivan, Caoimhe Hannigan, Hannah Wolfe

Experts in our system

1
Marina Annetta Lynch
Trinity College Dublin
Total Publications: 80
 
2
Ian H Robertson
Trinity College Dublin
Total Publications: 162
 
3
Brian A. Lawlor
National College Ireland
Total Publications: 125
 
4
Sabina Brennan
National College Ireland
Total Publications: 47
 
5
Michael O'Sullivan
National College Ireland
Total Publications: 12
 
6
Caoimhe Hannigan
National College Ireland
Total Publications: 58
 
7
Hannah Wolfe
National College Ireland
Total Publications: 7