Type

Journal Article

Authors

John Newell
Dietrich Rebholz-Schuhmann
Noel E. O'Connor
Kieran Moran
Kevin McGuinness
Joseph Antony
Jaynal Abedin

Subjects

Computer Science

Topics
x ray neural network patient data linear mixed models predictive models grading scheme osteoarthritis knee patient monitoring

Predicting knee osteoarthritis severity: comparative modeling based on patient's data and plain X-ray images. (2018)

Abstract Knee osteoarthritis (KOA) is a disease that impairs knee function and causes pain. A radiologist reviews knee X-ray images and grades the severity level of the impairments according to the Kellgren and Lawrence grading scheme; a five-point ordinal scale (0-4). In this study, we used Elastic Net (EN) and Random Forests (RF) to build predictive models using patient assessment data (i.e. signs and symptoms of both knees and medication use) and a convolution neural network (CNN) trained using X-ray images only. Linear mixed effect models (LMM) were used to model the within subject correlation between the two knees. The root mean squared error for the CNN, EN, and RF models was 0.77, 0.97 and 0.94 respectively. The LMM shows similar overall prediction accuracy as the EN regression but correctly accounted for the hierarchical structure of the data resulting in more reliable inference. Useful explanatory variables were identified that could be used for patient monitoring before X-ray imaging. Our analyses suggest that the models trained for predicting the KOA severity levels achieve comparable results when modeling X-ray images and patient data. The subjectivity in the KL grade is still a primary concern.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

John Newell, Dietrich Rebholz-Schuhmann, Noel E. O'Connor, Kieran Moran, Kevin McGuinness, Joseph Antony, Jaynal Abedin

Experts in our system

1
John Newell
University of Limerick
Total Publications: 51
 
2
Dietrich Rebholz-Schuhmann
Dublin City University
Total Publications: 3
 
3
Noel E. O'Connor
Dublin City University
Total Publications: 474
 
4
Kieran Moran
Dublin City University
Total Publications: 156
 
5
Kevin McGuinness
Dublin City University
Total Publications: 93
 
6
Joseph Antony
Dublin City University
Total Publications: 10