Type

Journal Article

Authors

Martin Clynes
Finbarr O'Sullivan
Richard Murphy
Karina Horgan
Joanne Keenan
Charles O'Doherty

Subjects

Veterinary

Topics
cell function media dose caco 2 cells cell line intestinal absorption humans copper

Copper-induced non-monotonic dose response in Caco-2 cells. (2018)

Abstract Copper is an essential dietary micronutrient in humans for proper cell function; however, in excess, it is toxic. The human cell line Caco-2 is popular as an in vitro model for intestinal absorption and toxicology. This study investigated the response of exponentially growing Caco-2 cells to prolonged copper exposure (120 h). An unexpected non-monotonic dose-response profile was observed in Caco-2 cells. Exposure to media supplemented with 3.125 μM CuSO
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Martin Clynes, Finbarr O'Sullivan, Richard Murphy, Karina Horgan, Joanne Keenan, Charles O'Doherty

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 232
 
2
Finbarr O'Sullivan
Dublin City University
Total Publications: 24
 
3
Richard Murphy
Dublin City University
 
4
Karina Horgan
Dublin City University
Total Publications: 6
 
5
Joanne Keenan
Dublin City University
Total Publications: 27