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Type

Journal Article

Authors

Noel G McElvaney
Andrew A Wilson
Pauline M Rudd
Darrell N Kotton
Derek C Liberti
Joanne Keenan
Paula Meleady
Michael Henry
Vipatsorn Shutchaidat
Oliver J McElvaney
and 8 others

Subjects

Biochemistry

Topics
plasma phase glycoprotein deficiency alpha 1 antitrypsin anti inflammatory capacity protein

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. (2018)

Abstract Alpha-1 antitrypsin (AAT) is an acute phase protein that possesses immune-regulatory and anti-inflammatory functions independent of antiprotease activity. AAT deficiency (AATD) is associated with early-onset emphysema and chronic obstructive pulmonary disease. Of interest are the AATD nonsense mutations (termed null or Q0), the majority of which arise from premature termination codons in the mRNA coding region. We have recently demonstrated that plasma from an AATD patient homozygous for the Null Bolton allele (
Url http://www.ncbi.nlm.nih.gov/pubmed/30796179
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Noel G McElvaney, Andrew A Wilson, Pauline M Rudd, Darrell N Kotton, Derek C Liberti, Joanne Keenan, Paula Meleady, Michael Henry, Vipatsorn Shutchaidat, Oliver J McElvaney and 8 others

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Biochemistry Microbiology
Total Publications: 194
 
2
Pauline M Rudd
University College Dublin
Microbiology Biochemistry Chemistry
Total Publications: 45
 
3
Joanne Keenan
Dublin City University
Biochemistry Microbiology
Total Publications: 27
 
4
Paula Meleady
Dublin City University
Biochemistry Microbiology
Total Publications: 115
 
5
Michael Henry
Dublin City University
Biochemistry
Total Publications: 99
 
6
Oliver J McElvaney
Royal College of Surgeons in Ireland
Biochemistry Microbiology Medicine & Nursing
Total Publications: 13