Type

Journal Article

Authors

Kay Ohlendieck
Dieter Swandulla
Rustam R Mundegar
Paula Meleady
Michael Henry
Margit Zweyer
Sandra Murphy

Subjects

Biochemistry

Topics
fatty acid mass spectrometry membrane protein cellular response stress response complex system muscle skeletal muscular dystrophy duchenne

Proteomic profiling of liver tissue from the (2018)

Abstract Duchenne muscular dystrophy is a highly complex multi-system disease caused by primary abnormalities in the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle degeneration, this neuromuscular disorder is also associated with pathophysiological perturbations in many other organs including the liver. To determine potential proteome-wide alterations in liver tissue, we have used a comparative and mass spectrometry-based approach to study the dystrophic The comparative proteomic profiling of The proteomic analysis revealed changes in a variety of protein families, affecting especially fatty acid, carbohydrate and amino acid metabolism, biotransformation, the cellular stress response and ion handling in the The proteomic results presented here indicate that the intricate and multifaceted pathogenesis of the
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Kay Ohlendieck, Dieter Swandulla, Rustam R Mundegar, Paula Meleady, Michael Henry, Margit Zweyer, Sandra Murphy

Experts in our system

1
Kay Ohlendieck
Maynooth University
Total Publications: 131
 
2
Dieter Swandulla
Maynooth University
Total Publications: 26
 
3
Rustam R Mundegar
Maynooth University
Total Publications: 17
 
4
Paula Meleady
Dublin City University
Total Publications: 115
 
5
Michael Henry
Dublin City University
Total Publications: 99
 
6
Margit Zweyer
Maynooth University
Total Publications: 24
 
7
Sandra Murphy
Maynooth University
Total Publications: 32