Type

Journal Article

Authors

Robert J Forster
Luisa De Cola
Richard O'Kennedy
Hui Ma
Kellie Adamson
Serena Carrara
Elaine Spain

Subjects

Chemistry

Topics
electrochemical detection cardiac impedance cardiac events monoclonal antibody point of care early detection electrochemical impedance spectroscopy

Cardiac Troponin I: Ultrasensitive Detection Using Faradaic Electrochemical Impedance. (2018)

Abstract An electrochemical biosensor for the detection of cardiac troponin I, cTnI, an important cardiac biomarker, is described. A combination of a novel monoclonal antibody, mAb20B3, and a novel Ir(III)-based metal complex was used for detection using faradaic electrochemical impedance spectroscopy. A limit of detection of 10 ag/mL was achieved, which is significantly lower than established assays. The ability to detect these ultralow concentrations enables rapid and early stage detection of cardiac events and opens up the possibility of developing a point-of-care device.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Robert J Forster, Luisa De Cola, Richard O'Kennedy, Hui Ma, Kellie Adamson, Serena Carrara, Elaine Spain

Experts in our system

1
Robert J. Forster
Dublin City University
Total Publications: 92
 
2
R O'Kennedy
Dublin City University
Total Publications: 211
 
3
Hui Ma
Dublin City University
Total Publications: 15
 
4
Kellie Adamson
Dublin City University
Total Publications: 8
 
5
Elaine Spain
Dublin City University
Total Publications: 15