Type

Journal Article

Authors

Pouya Khankhanian
Henrik Hjalgrim
Wendy Cozen
Jorge R Oksenberg
Pierre-Antoine Gourraud
Lohith Madireddy
Zachary Taub
Yolanda Benavente
Yawei Zhang
Tongzhang Zheng
and 82 others

Subjects

Medicine & Nursing

Topics
lymphoma non hodgkin lupus erythematosus systemic genome wide association studies genetic variation lymphoma large b cell diffuse autoimmune diseases chronic lymphocytic leukemia multiple sclerosis

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes. (2019)

Abstract Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Pouya Khankhanian, Henrik Hjalgrim, Wendy Cozen, Jorge R Oksenberg, Pierre-Antoine Gourraud, Lohith Madireddy, Zachary Taub, Yolanda Benavente, Yawei Zhang, Tongzhang Zheng and 82 others

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