Type

Journal Article

Authors

John Crown
Annette T Byrne
Brian Moulton
Dimitrios Tryfonopoulos
Bonnie Ky
William M Gallagher
Norma O'Donovan
Verena Murphy
Mairin Rafferty
Patrick Dicker
and 23 others

Subjects

Medicine & Nursing

Topics
breast cancer patients her 2 phase iii survival rate triple negative disease free survival three phase breast cancer

Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis of candidate circulating markers of cardiac toxicity: ICORG 08-10 trial. (2018)

Abstract Combining bevacizumab and chemotherapy produced superior response rates compared with chemotherapy alone in metastatic breast cancer. As bevacizumab may cause hypertension (HTN) and increase the risk of cardiac failure, we performed a pilot study to evaluate the feasibility and toxicity of a non-anthracycline-containing combination of docetaxel with cyclophosphamide and bevacizumab in early stage breast cancer patients. Treatment consisted of four 3-weekly cycles of docetaxel and cyclophosphamide (75/600 mg/m A total of 106 patients were accrued in nine sites. Median follow up was 65 months (1-72 months). Seventeen protocol-defined relapse events were observed, accounting for an overall disease-free survival (DFS) rate of 84%. The DFS rates for hormone receptor positive (HR+) and triple-negative (TN) patients were 95% We observed a low relapse rate in node-positive, HR+ patients; however, results in TN breast cancer were less encouraging. Given the negative results of three large phase III trials, it is unlikely that this approach will be investigated further. ClinicalTrials.gov Identifier: NCT00911716.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

John Crown, Annette T Byrne, Brian Moulton, Dimitrios Tryfonopoulos, Bonnie Ky, William M Gallagher, Norma O'Donovan, Verena Murphy, Mairin Rafferty, Patrick Dicker and 23 others

Experts in our system

1
John Crown
Dublin City University
Total Publications: 104
 
2
Annette T Byrne
Royal College of Surgeons in Ireland
Total Publications: 41
 
3
D Tryfonopoulos
Dublin City University
Total Publications: 7
 
4
William M Gallagher
University College Dublin
Total Publications: 148
 
5
Norma O'Donovan
Dublin City University
Total Publications: 59
 
6
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95