Type

Journal Article

Authors

Annette T Byrne
John Crown
Robert S Kerbel
Norma O'Donovan
William M Gallagher
Patrick Dicker
Kate Connor
Emer Conroy
Liam P Shiels
Ian S Miller

Subjects

Medicine & Nursing

Topics
breast cancer mice scid pre clinical cell line tumor cell models clinical trials tumor growth tumor microenvironment

Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents. (2019)

Abstract Angiogenesis is a key tumor microenvironment (TME) event underpinning tumor growth and metastasis. Nevertheless, the relatively poor performance of anti-angiogenic therapies in clinical trials compared to pre-clinical studies implies that classical subcutaneous xenograft models have limited predictive potential in this setting. To address this issue, we established orthotopic surgical resection models of breast cancer, which replicate the phenotype of clinical post-resection micro-metastasis. To demonstrate the power and precision of these models, we recapitulated the BETH adjuvant trial (NCT00625898) where the addition of bevacizumab (BVZ) to chemotherapy plus trastuzumab (Trast) failed to provide additional benefit. SCID mice were orthotopically implanted with bioluminescent Her2
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Annette T Byrne, John Crown, Robert S Kerbel, Norma O'Donovan, William M Gallagher, Patrick Dicker, Kate Connor, Emer Conroy, Liam P Shiels, Ian S Miller

Experts in our system

1
Annette T Byrne
Royal College of Surgeons in Ireland
Total Publications: 41
 
2
John Crown
Dublin City University
Total Publications: 104
 
3
Norma O'Donovan
Dublin City University
Total Publications: 59
 
4
William M Gallagher
University College Dublin
Total Publications: 148
 
5
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
 
6
Emer Conroy
Royal College of Surgeons in Ireland
Total Publications: 8
 
7
Ian S Miller
University College Dublin
Total Publications: 14