Type

Journal Article

Authors

Jacintha O'Sullivan
John V Reynolds
Joanne Lysaght
Lorraine Brennan
Graham P Pidgeon
Melissa J Conroy
Aoife Cannon
Eibhlin Carr
Rory Casey
Suzanne L Doyle
and 2 others

Subjects

Biochemistry

Topics
cancer patients nuclear receptor oesophageal adenocarcinoma gene expression cell survival adipose tissue magnetic resonance spectroscopy nuclear magnetic resonance

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma. (2018)

Abstract Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity status alter radiosensitivity in OAC. The radioresistant (OE33R) and radioresponsive (OE33P) OAC isogenic model was cultured with adipose tissue conditioned media from three patient cohorts: non-cancer patients, surgery only OAC patients and NA CRT OAC patients. Cell survival was characterised by clonogenic assay, metabolomic profiling by nuclear magnetic resonance spectroscopy and adipokine receptor gene expression by qPCR. A retrospective
Collections Ireland -> Dublin Institute of Technology -> PubMed

Full list of authors on original publication

Jacintha O'Sullivan, John V Reynolds, Joanne Lysaght, Lorraine Brennan, Graham P Pidgeon, Melissa J Conroy, Aoife Cannon, Eibhlin Carr, Rory Casey, Suzanne L Doyle and 2 others

Experts in our system

1
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
2
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
3
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
4
Lorraine Brennan
University College Dublin
Total Publications: 166
 
5
Graham Pidgeon
Trinity College Dublin
Total Publications: 38
 
6
Melissa J Conroy
Trinity College Dublin
Total Publications: 14
 
7
Aoife Cannon
TU Dublin
 
8
Eibhlin Carr
Trinity College Dublin
Total Publications: 3
 
9
Rory Casey
Trinity College Dublin
Total Publications: 4
 
10
Suzanne L Doyle
Trinity College Dublin
Total Publications: 23