Type

Journal Article

Authors

Andrew Hogan
Donal O'Shea
Lydia Lynch
Derek G Doherty
Desmond C Winter
Jean O'Connell
Declan Cody
Justin Geoghegan
Greg Byrne
Gadintshware Gaoatswe
and 4 others

Subjects

Medicine & Nursing

Topics
adipose tissue il 17 insulin resistance children adults il 10 t cells childhood obesity obese children

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity (2015)

Abstract Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through the rapid production of cytokines. In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion is associated with diabetic status. Circulating MAIT cells more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated in insulin resistance. MAIT cells were enriched in adipose tissue (AT) compared with blood. AT MAIT cells, but not circulating MAIT cells, were capable of producing IL-10. In AT from obese subjects, MAIT cells were depleted, were less likely to produce IL-10, and more frequently produced IL-17. Finally, we show that IL-17+ MAIT cells are also increased in childhood obesity, and altered MAIT cell frequencies in obese children are positively associated with insulin resistance. These data indicate that MAIT cells are enriched in human AT and display an IL-17+ phenotype in both obese adults and children, correlating with levels of insulin resistance. The alterations in MAIT cells may be contributing to obesity-related sterile inflammation and insulin resistance.
Collections Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Biology
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Status = Published

Full list of authors on original publication

Andrew Hogan, Donal O'Shea, Lydia Lynch, Derek G Doherty, Desmond C Winter, Jean O'Connell, Declan Cody, Justin Geoghegan, Greg Byrne, Gadintshware Gaoatswe and 4 others

Experts in our system

1
Andrew Hogan
Maynooth University
Total Publications: 37
 
2
Donal F O'Shea
University College Dublin
Total Publications: 136
 
3
Lydia Lynch
Trinity College Dublin
Total Publications: 23
 
4
Derek Doherty
Trinity College Dublin
Total Publications: 52
 
5
Desmond C. Winter
University College Dublin
Total Publications: 53
 
6
Jean O'Connell
Maynooth University
 
7
Declan Cody
Maynooth University
Total Publications: 6
 
8
Justin Geoghegan
Trinity College Dublin
Total Publications: 14
 
9
Greg Byrne
Dublin Institute of Technology
Total Publications: 16