Type

Journal Article

Authors

Małgorzata Wygrecka
Oliver J McElvaney
Bernd Schmeck
Timm Greulich
Wilhelm Bertrams
Gunter Lochnit
Jay Kearney
Alicja Misiak
Alexander Hooftman
Dylan G Ryan
and 12 others

Subjects

Microbiology

Topics
inflammation activated caspase 1 and caspase 11 asthma health immunology inflammation infection chronic health condition pyroptosis caspase

Caspase-11 promotes allergic airway inflammation (2020)

Abstract Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 suppreses caspase-11 expression in murine and human macrophages and in the airways of mice with allergic inflammation. Remarkably, caspase-11-deficient mice are strongly resistant to developing experimental allergic airway inflammation, where PGE2 is known to be protective. Expression of caspase-11 is elevated in the lung of wild type mice with allergic airway inflammation. Blocking PGE2 production with indomethacin enhances, whereas the prostaglandin E1 analog misoprostol inhibits lung caspase-11 expression. Finally, alveolar macrophages from asthma patients exhibit increased expression of caspase-4, a human homologue of caspase-11. Our findings identify PGE2 as a negative regulator of caspase-11-driven pyroptosis and implicate caspase-4/11 as a critical contributor to allergic airway inflammation, with implications for pathophysiology of asthma
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Full list of authors on original publication

Małgorzata Wygrecka, Oliver J McElvaney, Bernd Schmeck, Timm Greulich, Wilhelm Bertrams, Gunter Lochnit, Jay Kearney, Alicja Misiak, Alexander Hooftman, Dylan G Ryan and 12 others

Experts in our system

1
Oliver J McElvaney
Royal College of Surgeons in Ireland
 
2
Alicja Misiak
Trinity College Dublin
Total Publications: 10
 
3
Dylan G Ryan
Trinity College Dublin
Total Publications: 5