Journal Article


Donagh P. Berry
M L Doherty
R D Evans
A Blom
E Ryan
P. Breslin
M Good
D C Purfield
Daniel Bradley
S C Ring



genome analysis holstein friesian quantitative trait loci bovine tuberculosis btb data analysis genome wide association beef sequence analysis alleles association analysis cattle whole genome sequence data mycobacterium bovis bovine tuberculosis infection genomics bovine tuberculosis genetic polymorphism molecular genetics genome wide association studies single snp regression linear mixed models

Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data (2019)

Abstract Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in Republic of Ireland was the biological extinction of bTB; that purpose has yet to be achieved. Objectives of the present study were to develop the statistical methodology and variance components to undertake routine genetic evaluations for resistance to bTB; also of interest was the detection of regions of the bovine genome putatively associated with bTB infection in dairy and beef breeds. The novelty of the present study, in terms of research on bTB infection, was the use of beef breeds in the genome-wide association and the utilization of imputed whole genome sequence data. Phenotypic bTB data on 781,270 animals together with imputed whole genome sequence data on 7,346 of these animals’ sires were available. Linear mixed models were used to quantify variance components for bTB and EBVs were validated. Within-breed and multi-breed genome-wide associations were undertaken using a single-SNP regression approach. The estimated genetic standard deviation (0.09), heritability (0.12), and repeatability (0.30) substantiate that genetic selection help to eradicate bTB. The multi-breed genome-wide association analysis identified 38 SNPs and 64 QTL regions associated with bTB infection; two QTL regions (both on BTA23) identified in the multi-breed analysis overlapped with the within-breed analyses of Charolais, Limousin, and Holstein-Friesian. Results from the association analysis, coupled with previous studies, suggest bTB is controlled by an infinitely large number of loci, each having a small effect. The methodology and results from the present study will be used to develop national genetic evaluations for bTB in the Republic of Ireland. In addition, results can also be used to help uncover the biological architecture underlying resistance to bTB infection in cattle.
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Full list of authors on original publication

Donagh P. Berry, M L Doherty, R D Evans, A Blom, E Ryan, P. Breslin, M Good, D C Purfield, Daniel Bradley, S C Ring

Experts in our system

D P Berry
Total Publications: 243
Michael L. Doherty
Total Publications: 119
R. D. Evans
Total Publications: 44
M Good
University College Dublin
Total Publications: 32
Deirdre C Purfield
Total Publications: 23
Daniel Bradley
Trinity College Dublin
Total Publications: 84
S C Ring
Total Publications: 6