Type

Journal Article

Authors

Adriele Prina-Mello
Yuri Volkov
Stephen Smith

Subjects

Chemistry

Topics
healthcare silver nanoparticles human skin models hollow fibre flow field flow fractionation cellular toxicity silver nanoparticle based antimicrobials coating agents

Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents (2018)

Abstract Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of the particles (size, shape, surface charge, ionic content) with their specific activity. In this paper, we propose an effective multi-step approach for the identification of a ‘purpose-specific active applicability window’ to maximize the antimicrobial activity of medical devices containing silver nanoparticles (Ag NPs) (such as surface coaters), minimizing any consequent risk for human health (safety by design strategy). The antimicrobial activity and the cellular toxicity of four types of Ag NPs, differing in their coating composition and concentration have been quantified. Through the implementation of flowfield flow fractionation, Ag NPs have been characterized in terms of metal release, size and shape. The particles are fractionated in the process while being left unmodified, allowing for the identification of biological particle-specific contribution. Toxicity and inflammatory response in vitro have been assessed on human skin models, while antimicrobial
Collections Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> Clinical Medicine
Ireland -> Trinity College Dublin -> Clinical Medicine (Scholarly Publications)
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> School of Medicine

Full list of authors on original publication

Adriele Prina-Mello, Yuri Volkov, Stephen Smith

Experts in our system

1
Adriele Prina-Mello
Trinity College Dublin
Total Publications: 25
 
2
Yuri Volkov
Trinity College Dublin
Total Publications: 70
 
3
Stephen Smith
Trinity College Dublin
Total Publications: 27