Type

Journal Article

Authors

Juliette Hussey
Jacintha O'Sullivan
Jessie Elliott
Linda O'Neill
Suzanne Doyle
Emer Guinan
John Reynolds
G Foley
Annemarie Bennett
J Gannon

Subjects

Medicine & Nursing

Topics
cancer health related quality oesophageal cancer physical activity physical activity study survivorship care cancer survivorship physical functioning physical activity participation biochemistry biophysics and structural biology health related quality of life health life

Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study (2019)

Abstract Background: Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quantified. This study prospectively examines change in physical functioning and habitual physical activity participation, from pre-surgery through 6-months post-oesophagectomy. Methods: Patients scheduled for oesophagectomy with curative intent were recruited. Key domains of physical functioning including exercise tolerance (six-minute walk test (6MWT)) and muscle strength (hand-grip strength), and habitual physical activity participation, including sedentary behaviour (accelerometry) were measured pre-surgery (T0) and repeated at 1-month (T1) and 6-months (T2) post-surgery. HR-QOL was measured using the EORTC-QOL C30. Results: Thirty-six participants were studied (mean age 62.4 (8.8) years,n= 26 male, n = 26 transthoracic oesophagectomy). Mean 6MWT distance decreased significantly from T0 to T1 (p= 0.006) and returned to T0 levels between T1 and T2 (p< 0.001). Percentage time spent sedentary increased throughout recovery (p< 0.001) and remained significantly higher at T2 in comparison to T0 (p= 0.003). In contrast, percentage time spent engaged in either light or moderate-to-vigorous intensity activity, all reduced significantly (p < 0.001 for both) and remained significantly lower at T2 in comparison to T0 (p= 0.009 andp= 0.01 respectively). Patients reported deficits in multiple domains of HR-QOL during recovery including global health status (p= 0.04), physical functioning (p <0.001) and role functioning (p < 0.001). Role functioning remained a clinically important 33-points lower than pre-operative values at T2. Conclusion: Habitual physical activity participation remains significantly impaired at 6-months post-oesophagectomy. Physical activity is a measurable and modifiable target for physical rehabilitation, which is closely aligned with patient-reported deficits in role functioning. Rehabilitation aimed at optimising physical health in oesophageal cancer survivorship is warranted.
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Full list of authors on original publication

Juliette Hussey, Jacintha O'Sullivan, Jessie Elliott, Linda O'Neill, Suzanne Doyle, Emer Guinan, John Reynolds, G Foley, Annemarie Bennett, J Gannon

Experts in our system

1
Juliette Hussey
Trinity College Dublin
Total Publications: 45
 
2
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
3
Linda O'Neill
Trinity College Dublin
 
4
Suzanne L Doyle
Trinity College Dublin
Total Publications: 23
 
5
Emer Guinan
Trinity College Dublin
Total Publications: 33
 
6
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
7
G Foley
Dublin Institute of Technology
 
8
Annemarie Bennett
Dublin Institute of Technology
Total Publications: 17
 
9
J Gannon
Trinity College Dublin