Type

Journal Article

Authors

Abraham Reichenberg
Gunter Schumann
Henrik Walter
Dimitri Papadopoulos Orfanos
Frauke Nees
Eric Artiges
Marie-Laure Paillère Martinot
Bernd Ittermann
Andreas Heinz
Penny Gowland
and 15 others

Subjects

Psychiatry

Topics
structural equation modeling autism spectrum disorder autism follow up psychotic experiences pes social processes schizophrenia psychosis

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis (2018)

Abstract While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work suggests that PEs may only represent significant risk when accompanied by social impairment. Leveraging data from the large longitudinal IMAGEN cohort, including 2096 14-year old adolescents that were followed-up to age 18, we tested whether the association between polygenic risk and PEs is mediated by (increasing) impairments in social functioning and social cognitive processes. Using structural equation modeling (SEM) for the subset of participants (n = 643) with complete baseline and follow-up data, we examined pathways to PEs. We found that high polygenic risk for schizophrenia (p = 0.014), reduced brain activity to emotional stimuli (p = 0.009) and social impairments in late adolescence (p < 0.001; controlling for functioning in early adolescence) each independently contributed to the severity of PEs at age 18. The pathway between polygenic risk for autism spectrum disorder and PEs was mediated by social impairments in late adolescence (indirect pathway; p = 0.025). These findings point to multiple direct and indirect pathways to PEs, suggesting that different processes are in play, depending on genetic loading, and environment. Our results suggest that treatments targeting prevention of social impairment may be particularly promising for individuals at genetic risk for autism in order to minimize risk for psychosis.
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Full list of authors on original publication

Abraham Reichenberg, Gunter Schumann, Henrik Walter, Dimitri Papadopoulos Orfanos, Frauke Nees, Eric Artiges, Marie-Laure Paillère Martinot, Bernd Ittermann, Andreas Heinz, Penny Gowland and 15 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Frauke Nees
Trinity College Dublin
Total Publications: 63
 
3
Andreas Heinz
Trinity College Dublin
Total Publications: 65