Type

Journal Article

Authors

Harald Hampel
Michel Thiebaut de Schotten
Bruno Dubois
Marie-Odile Habert
Marie-Claude Potier
Simone Lista
Andrea Vergallo
Enrica Cavedo
Patrizia A Chiesa
Arun Bokde

Subjects

Psychiatry

Topics
disease risk brain functional dynamics subjective memory complaints default mode precision medicine alzheimer s disease risk factors fmri

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease (2019)

Abstract Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E ε4 (APOE ε4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion: For the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions.
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Full list of authors on original publication

Harald Hampel, Michel Thiebaut de Schotten, Bruno Dubois, Marie-Odile Habert, Marie-Claude Potier, Simone Lista, Andrea Vergallo, Enrica Cavedo, Patrizia A Chiesa, Arun Bokde

Experts in our system

1
Harald Hampel
Trinity College Dublin
Total Publications: 35
 
2
Bruno Dubois
Trinity College Dublin
Total Publications: 8
 
3
Simone Lista
Trinity College Dublin
Total Publications: 7
 
4
Enrica Cavedo
Trinity College Dublin
Total Publications: 10
 
5
Arun L W Bokde
Trinity College Dublin
Total Publications: 144