Type

Journal Article

Authors

Carlos Medina
Nadhim Kamil Hante
Maria Santos-Martinez

Subjects

Chemistry

Topics
nanoscience materials aggregation platelets nanoparticles charge metallic nanoparticles nanoparticles shape activation cytoxicity nanoparticles

Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications (2019)

Abstract Nanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can translocate into the systemic circulation even after dermal contact, inhalation, or oral ingestion. Once in the blood stream, nanoparticles become in contact with the different components of the blood and can potentially interfere with normal platelet function leading to bleeding or thrombosis. Metallic NPs have been already used for diagnosis and treatment purposes due to their unique characteristics. However, the potential interactions between metallic NPs and platelets has not been widely studied and reported. This review focuses on the factors that can affect platelet activation and aggregation by metal NPs and the nature of such interactions, providing a summary of the effect of various metal NPs on platelet function available in the literature.
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Full list of authors on original publication

Carlos Medina, Nadhim Kamil Hante, Maria Santos-Martinez

Experts in our system

1
Carlos Medina
Trinity College Dublin
Total Publications: 23
 
2
Maria Jose Santos-Martinez
Trinity College Dublin
Total Publications: 29