Type

Journal Article

Authors

Eva M Jimenez-Mateos
David C Henshall
Tríona Ní Chonghaile
Jochen H M Prehn
Heiko Düssmann
Alessandra Di Grande
Paula Merino-Serrais
Sean Quinlan

Subjects

Pharmacology

Topics
hypoxia anti inflammatory seizures microglia neonatal encephalopathy inflammation therapeutic targets novel the

The anti-inflammatory compound candesartan cilexetil improves neurological outcomes in a mouse model of neonatal hypoxia (2019)

Abstract Recent studies suggest that mild hypoxia-induced neonatal seizures can trigger an acute neuroinflammatory response leading to long-lasting changes in brain excitability along with associated cognitive and behavioral deficits. The cellular elements and signaling pathways underlying neuroinflammation in this setting remain incompletely understood but could yield novel therapeutic targets. Here we show that brief global hypoxia-induced neonatal seizures in mice result in transient cytokine production, a selective expansion of microglia and long-lasting changes to the neuronal structure of pyramidal neurons in the hippocampus. Treatment of neonatal mice after hypoxia-seizures with the novel anti-inflammatory compound candesartan cilexetil suppressed acute seizure-damage and mitigated later-life aggravated seizure responses and hippocampus-dependent learning deficits. Together, these findings improve our understanding of the effects of neonatal seizures and identify potentially novel treatments to protect against short and long-lasting harmful effects.
Collections Ireland -> University College Cork -> INFANT Research Centre
Ireland -> University College Cork -> INFANT Research Centre - Journal Articles
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Full list of authors on original publication

Eva M Jimenez-Mateos, David C Henshall, Tríona Ní Chonghaile, Jochen H M Prehn, Heiko Düssmann, Alessandra Di Grande, Paula Merino-Serrais, Sean Quinlan

Experts in our system

1
Eva M Jimenez-Mateos
Royal College of Surgeons in Ireland
Total Publications: 55
 
2
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127
 
3
Tríona Ní Chonghaile
Royal College of Surgeons in Ireland
Total Publications: 4
 
4
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
5
Heiko Düssmann
Royal College of Surgeons in Ireland
Total Publications: 45
 
6
Sean Quinlan
Royal College of Surgeons in Ireland
Total Publications: 6