Type

Journal Article

Authors

James M. Kinross
Julian R Marchesi
Daniel W. Rosenberg
Paul W. O'Toole
Jeremy Burton
Hans Verstraelen
David J Hughes
Jun Yu
Julian Teare
H. Rex Gaskins
and 8 others

Subjects

Medicine & Nursing

Topics
environmental factors expert opinion human longitudinal studies carcinogenesis cohort studies microbiome cancer

International cancer microbiome consortium consensus statement on the role of the human microbiome in carcinogenesis (2019)

Abstract Objective In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis.Design International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research.Results Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an‚ÄČaltered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis.Conclusion Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
Collections Ireland -> University College Cork -> APC Microbiome Institute
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> APC Microbiome Institute- Journal Articles
Ireland -> University College Cork -> Microbiology
Ireland -> University College Cork -> Research Institutes and Centres
Ireland -> University College Cork -> Microbiology - Journal Articles

Full list of authors on original publication

James M. Kinross, Julian R Marchesi, Daniel W. Rosenberg, Paul W. O'Toole, Jeremy Burton, Hans Verstraelen, David J Hughes, Jun Yu, Julian Teare, H. Rex Gaskins and 8 others

Experts in our system

1
Julian R Marchesi
University College Cork
Total Publications: 45
 
2
Paul W. O'Toole
University College Cork
Total Publications: 93
 
3
David J Hughes
Royal College of Surgeons in Ireland
Total Publications: 24