Type

Journal Article

Authors

Gary Donohoe
Aiden Corvin
Michael Gill
Thomas Frodl
Hazel McCarthy
Derek W Morris
Noreen Tangney
Omar Mothersill

Subjects

Psychiatry

Topics
functional magnetic resonance imaging cognitive psychology large scale evidence theory network theory prefrontal cortex psychology functional connectivity

Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia (2017)

Abstract Background Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity changes and behaviour (e.g. symptoms, neuropsychological performance) remains unclear. Methods Functional connectivity in 27 patients with schizophrenia or schizoaffective disorder, and 25 age and gender matched healthy controls was examined using rs-fMRI. Based on seed regions from previous studies, we examined functional connectivity of the default, cognitive control, affective and attention networks. Effects of symptom severity and theory of mind performance on functional connectivity were also examined. Results Patients showed increased connectivity between key nodes of the default network including the precuneus and medial prefrontal cortex compared to controls (p < 0.01, FWE-corrected). Increasing positive symptoms and increasing theory of mind performance were both associated with altered connectivity of default regions within the patient group (p < 0.01, FWE-corrected). Discussion This study confirms previous findings of default hyper-connectivity in schizophrenia spectrum patients and reveals an association between altered default connectivity and positive symptom severity. As a novel find, this study also shows that default connectivity is correlated to and predictive of theory of mind performance. Extending these findings by examining the effects of emerging social cognition treatments on both default connectivity and theory of mind performance is now an important goal for research.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognitive psychology
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College Ireland -> Type = Article
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology

Full list of authors on original publication

Gary Donohoe, Aiden Corvin, Michael Gill, Thomas Frodl, Hazel McCarthy, Derek W Morris, Noreen Tangney, Omar Mothersill

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 162
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 218
 
3
Michael Gill
Trinity College Dublin
Total Publications: 294
 
4
Thomas Frodl
Trinity College Dublin
Total Publications: 60
 
5
Hazel McCarthy
Trinity College Dublin
Total Publications: 9
 
6
Derek Morris
Trinity College Dublin
Total Publications: 168
 
7
Omar Mothersill
National College Ireland
Total Publications: 31