Journal Article


Mark A Bellgrove
Redmond G O'Connell
Sanjay L. Nandam
Angela Dean
Jessica J.M. Barnes
Méadhbh B Brosnan
Gerard M Loughnane



modulation randomized psychology trial rc0321 neuroscience biological psychiatry neuropsychiatry formation randomized controlled decision making

Catecholamine Modulation of Evidence Accumulation during Perceptual Decision Formation: A Randomized Trial (2019)

Abstract Recent behavioral modeling and pupillometry studies suggest that neuromodulatory arousal systems play a role in regulating decision formation but neurophysiological support for these observations is lacking. We employed a randomized, double-blinded, placebo-controlled, crossover design to probe the impact of pharmacological enhancement of catecholamine levels on perceptual decision-making. Catecholamine levels were manipulated using the clinically relevant drugs methylphenidate and atomoxetine, and their effects were compared with those of citalopram and placebo. Participants performed a classic EEG oddball paradigm that elicits the P3b, a centro-parietal potential that has been shown to trace evidence accumulation, under each of the four drug conditions. We found that methylphenidate and atomoxetine administration shortened RTs to the oddball targets. The neural basis of this behavioral effect was an earlier P3b peak latency, driven specifically by an increase in its buildup rate without any change in its time of onset or peak amplitude. This study provides neurophysiological evidence for the catecholaminergic enhancement of a discrete aspect of human decision-making, that is, evidence accumulation. Our results also support theoretical accounts suggesting that catecholamines may enhance cognition via increases in neural gain.
Collections Ireland -> National College Ireland -> Subject = R Medicine: RC Internal medicine: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College Ireland -> Subject = R Medicine
Ireland -> National College Ireland -> Type = Article
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College Ireland -> Subject = R Medicine: RC Internal medicine

Full list of authors on original publication

Mark A Bellgrove, Redmond G O'Connell, Sanjay L. Nandam, Angela Dean, Jessica J.M. Barnes, Méadhbh B Brosnan, Gerard M Loughnane

Experts in our system

Mark A. Bellgrove
Trinity College Dublin
Total Publications: 39
Redmond G O'Connell
Trinity College Dublin
Total Publications: 59
Gerard M Loughnane
National College Ireland
Total Publications: 17