Type

Journal Article

Authors

Lorraine Brennan
Anne P Nugent
Breige A McNulty
Milena Rundle
Helena Gibbons
Xiaofei Yin

Subjects

Veterinary

Topics
dose response relationship insulin resistance fish intake trimethylamine n oxide nmr spectroscopy national nutrition survey dietary biomarkers metabolomics

The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide (2020)

Abstract Scope: Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free‐living population. Methods and results: In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine‐N‐oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose–response with intake (p < 0.05). Fish consumption yields a greater increase in urinary TMAO compared to red meat. Biomarker‐derived fish intake is calculated in the National Adult Nutrition Survey cross‐sectional study. However, the correlation between fish intake and TMAO (r = 0.148, p < 0.01) and that between fish intake and calculated fish intake (r = 0.142, p < 0.01) are poor. In addition, TMAO shows significantly positive correlation with serum insulin and insulin resistance in males and the relationship is more pronounced for males with high dietary fat intake. Conclusion: Urinary TMAO displays a strong dose–response relationship with fish intake; however, use of TMAO alone is insufficient to determine fish intake in a free‐living population.
Collections Ireland -> University College Dublin -> School of Agriculture and Food Science
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection
Ireland -> University College Dublin -> Institute of Food and Health
Ireland -> University College Dublin -> College of Health and Agricultural Sciences
Ireland -> University College Dublin -> Institute of Food and Health Research Collection
Ireland -> University College Dublin -> Institutes and Centres

Full list of authors on original publication

Lorraine Brennan, Anne P Nugent, Breige A McNulty, Milena Rundle, Helena Gibbons, Xiaofei Yin

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Anne P Nugent
University College Cork
 
3
Breige A McNulty
University College Cork
 
4
Milena Rundle
University College Dublin
Total Publications: 6
 
5
Helena Gibbons
University College Dublin
 
6
Xiaofei Yin
University College Dublin