Type

Journal Article

Authors

Lorraine Brennan
Albert Flynn
Janette Walton
Anne P Nugent
Breige A McNulty
Helena Gibbons
Diana González-Peña
Pedapati S C Sri Harsha
Cassandra Collins
Aoife E McNamara

Subjects

Agriculture & Food Science

Topics
apples food intake metabolomics dietary assessment clinical research prevention biomarkers nutrition

Metabolomic Based Approach to Identify Biomarkers of Apple Intake (2020)

Abstract SCOPE:There is an increased interest in developing biomarkers of food intake to address some of the limitations associated with self-reported data. The objective was to identify biomarkers of apple intake, examine dose-response relationships and agreement with self-reported data. METHODS AND RESULTS:Metabolomic data from three studies were examined: an acute intervention, a short-term intervention and a free-living cohort study. Fasting and postprandial urine samples were collected for analysis by 1 H-NMR and LC-MS. Calibration curves were developed to determine apple intake and classify individuals into categories of intake. Multivariate analysis of data revealed that levels of multiple metabolites increased significantly post-apple consumption, compared to the control food- broccoli. In the dose-response study, urinary xylose, epicatechin sulfate and 2, 6-dimethyl-2-(2-hydroxyethyl)-3,4-dihydro-2H-1-benzopyran increased as apple intake increased. Urinary xylose concentrations in a free-living cohort performed poorly at an individual level but were capable of ranking individuals in categories of intake. CONCLUSION:Urinary xylose exhibited a dose-response relationship with apple intake and performed well as a ranking biomarker in the population study. Other potential biomarkers were identified and future work will combine these with xylose in a biomarker panel which may allow for a more objective determination of individual intake.
Collections Ireland -> University College Dublin -> School of Agriculture and Food Science
Ireland -> University College Dublin -> Conway Institute Research Collection
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection
Ireland -> University College Dublin -> Institute of Food and Health
Ireland -> University College Dublin -> College of Health and Agricultural Sciences
Ireland -> University College Dublin -> Institute of Food and Health Research Collection
Ireland -> University College Dublin -> Conway Institute
Ireland -> University College Dublin -> Institutes and Centres

Full list of authors on original publication

Lorraine Brennan, Albert Flynn, Janette Walton, Anne P Nugent, Breige A McNulty, Helena Gibbons, Diana González-Peña, Pedapati S C Sri Harsha, Cassandra Collins, Aoife E McNamara

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Albert Flynn
University College Cork
Total Publications: 83
 
3
Janette Walton
University College Cork
Total Publications: 79
 
4
Anne P Nugent
University College Cork
 
5
Breige A McNulty
University College Cork
 
6
Helena Gibbons
University College Dublin
 
7
Cassandra Collins
Maynooth University
Total Publications: 9
 
8
Aoife E McNamara
University College Dublin