Type

Conference Proceedings

Authors

Peter Kelly
Martin O’Donohoe
Michael Marnane
Eoin Kavanagh
Shane J Foley
Morgan Crowe
Mary Barry
Jonathan P McNulty
Nicola Giannotti

Subjects

Psychology

Topics
relationship factors risk factors atherosclerotic plaque clinical practice stroke prevention mural plaque burden high resolution carotid stenosis

High-resolution MRI (HR-MRI) of atherosclerotic plaque in symptomatic carotid stenosis – relationship with risk factors, treatment, and CT angiographic features (2018)

Abstract Purpose: Traditional imaging techniques rely on arterial lumen stenosis as an indirect measure of mural plaque. HR-MRI allows direct imaging of mural plaque burden and composition. However, few data exist on the relationship of these parameters to clinical factors in patients with symptomatic carotid stenosis. We investigated the relationship between MR plaque features, clinical characteristics, and plaque morphology on CT angiography. Methods: A sub-group of patients included in the prospective BIOVASC plaque imaging study were included. Inclusion criteria were: (1) Speech/motor TIA or non-severe stroke (Rankin≤3) <72hours (2) Ipsilateral carotid stenosis ≥50% (3) Age≥50 (4) Carotid HR-MRI and CTA performed. Exclusions were pregnancy, malignancy, dementia, renal impairment, cervical irradiation/endarterectomy/stent. Semi-automated analysis of HR-MRI axial plaque images was done using PlaqueView and manual analysis of co-registered CTA performed. Results: 27 patients met inclusion criteria (78% men, mean age 66 years, 36% stroke/64%TIA, 39% current smoking). By HR-MRI, maximum plaque wall area was greater in patients with index stroke compared with TIA (p=0.007). Plaque maximum wall thickness was greater in diabetes (p=0.016) and statin-untreated patients (p=0.003). Volume of lipid-rich necrotic core was less (p=0.018) and fibrous cap thickness (p=0.05) greater in aspirin-treated patients. When HR-MRI was compared with CTA, high correlations were observed for lumen area (rho=0.976, p<0.001), maximum wall thickness (rho=0.878, p<0.001), and maximum wall area (Pearson r=0.981, p<0.001). Conclusion: If replicated, our findings may inform the application of plaque HR-MRI and CTA as surrogate markers in future clinical practice and randomised trials for stroke prevention.
Collections Ireland -> University College Dublin -> Medicine Research Collection
Ireland -> University College Dublin -> College of Health and Agricultural Sciences
Ireland -> University College Dublin -> School of Medicine

Full list of authors on original publication

Peter Kelly, Martin O’Donohoe, Michael Marnane, Eoin Kavanagh, Shane J Foley, Morgan Crowe, Mary Barry, Jonathan P McNulty, Nicola Giannotti

Experts in our system

1
Peter J Kelly
University College Dublin
Total Publications: 48
 
2
Michael Marnane
University College Dublin
Total Publications: 15
 
3
Eoin Kavanagh
University College Dublin
Total Publications: 17
 
4
Shane J Foley
University College Dublin
Total Publications: 6
 
5
Morgan Crowe
University of Limerick
Total Publications: 10
 
6
Mary Barry
University College Dublin
Total Publications: 6
 
7
Jonathan P McNulty
University College Dublin
Total Publications: 27