Journal Article


Helena Gibbons
Lorraine Brennan


Physiotherapy & Sport

sex precision nutrition meddiet dietary intake dietary interventions menstrual cycle mediterranean diet metabolomics

Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions (2019)

Abstract The metabolomic profile of a biofluid can be altered by dietary intake, exercise and disease processes and, thus provides an important tool for the study of many physiological processes. However, in addition to perturbation due to disease, the metabolomic profile of urine and plasma has also been shown to vary due to many intrinsic physiological factors such as age, sex, hormonal status and diurnal variation. Characterisation of this normal degree of variation in the metabolomic profiles of human biofluids is a necessary and important step in the development of metabolomics for use in nutrition-related research. The current review focuses on the impact of sex on the metabolomic profile. A number of studies have reported that sex impacts metabolites such as amino acids, lipids, sugars and keto acids. Furthermore, we examine the effect of the menstrual cycle on the metabolomic profile. Responses to dietary interventions can also differ between the sexes and highlighting this is important for the development of the field of precision nutrition.
Collections Ireland -> University College Dublin -> School of Agriculture and Food Science
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection
Ireland -> University College Dublin -> College of Health and Agricultural Sciences

Full list of authors on original publication

Helena Gibbons, Lorraine Brennan

Experts in our system

Helena Gibbons
University College Dublin
Lorraine Brennan
University College Dublin
Total Publications: 166