Type

Journal Article

Authors

Lorraine Brennan
S.C. Sri Harsha Pedapati
Victoria O'Sullivan
Elaine Drummond
Katy M Horner

Subjects

Pharmacology

Topics
gastric emptying amino acid amino acids gastric acid casein hplc ms ms hydrolysate postprandial glycaemia

Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses (2018)

Abstract Purpose Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. Methods Nine overweight and obese adults (mean ± SD age: 59.5 ± 6.5 years and BMI 28.4 ± 2.6 kg/m2) were studied in a randomised crossover design. Gastric emptying was assessed by paracetamol absorption test, with HPLC-MS being used for determining paracetamol and its primary metabolites in plasma. Glucose, insulin and amino acid responses were also assessed. Results Linear mixed model analysis showed no effect of treatment [F(1, 55) = 2.1, P = 0.16] or treatment × time interactions [F(6, 54) = 1.5, P = 0.21] for paracetamol concentrations. In addition, there were no significant differences between the intact casein and hydrolysate for any of the gastric emptying outcome measures (Cmax, AUC0–30min, AUC0–60min; AUC0–240min). However, insulin was increased in the early postprandial period (iAUC0–15min, iAUC0–30min; P < 0.05) and there was a treatment effect for glucose [F(1, 53) = 5.3, P = 0.03] following the casein hydrolysate compared to intact casein. No significant differences in amino acids were found between the two conditions. Conclusions Gastric emptying of a casein hydrolysate compared to intact casein does not differ. Mechanisms other than gastric emptying, for example the presence of a bioactive peptide sequence, may contribute to the glycaemic management effects of certain milk protein hydrolysates and warrant further investigation.
Collections Ireland -> University College Dublin -> School of Agriculture and Food Science
Ireland -> University College Dublin -> Public Health, Physiotherapy and Sports Science Research Collection
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection
Ireland -> University College Dublin -> College of Health and Agricultural Sciences
Ireland -> University College Dublin -> School of Public Health, Physiotherapy and Sports Science

Full list of authors on original publication

Lorraine Brennan, S.C. Sri Harsha Pedapati, Victoria O'Sullivan, Elaine Drummond, Katy M Horner

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Elaine Drummond
University College Dublin
Total Publications: 4
 
3
Katy M Horner
University College Dublin
Total Publications: 8