Type

Journal Article

Authors

Diane Benford
Vasileios Bampidis
Simon John More

Subjects

Medicine & Nursing

Topics
interactions health risk assessment combined exposure to multiple chemicals risk assessment dose addition mixtures response addition harmonised methodologies

Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals (2019)

Abstract This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk assessment of combined exposure to multiple chemicals. The framework is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterisation, and risk characterisation including uncertainty analysis), with tiered and stepwise approaches for both whole mixture approaches and componentā€based approaches. Specific considerations are given to componentā€based approaches including the grouping of chemicals into common assessment groups, the use of dose addition as a default assumption, approaches to integrate evidence of interactions and the refinement of assessment groups. Case studies are annexed in this guidance document to explore the feasibility and spectrum of applications of the proposed methods and approaches for human and animal health and ecological risk assessment. The Scientific Committee considers that this Guidance is fit for purpose for risk assessments of combined exposure to multiple chemicals and should be applied in all relevant areas of EFSA's work. Future work and research are recommended.
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Ireland -> University College Dublin -> College of Health and Agricultural Sciences

Full list of authors on original publication

Diane Benford, Vasileios Bampidis, Simon John More

Experts in our system

1
Diane Benford
University College Dublin
Total Publications: 6
 
2
S J More
University College Dublin
Total Publications: 213