Type

Journal Article

Authors

Eamonn Gormley
Simon John More
Eoin Ryan
Mairead B Doyle
Tracy A Clegg

Subjects

Veterinary

Topics
cattle mycobacterium bovis diagnostics single intradermal comparative tuberculin test sictt risk factors ifn test post mortem tuberculosis

Characteristics of Mycobacterium bovis infected herds tested with the interferon-gamma assay (2019)

Abstract The IFN-γ (interferon gamma) assay is used in Ireland as an ancillary diagnostic test to the single intradermal comparative tuberculin test (SICTT) to maximise the detection of Mycobacterium bovis infected animals (bTB) in cattle herds. Understanding the relationships between herd and animal risk factors and IFN-γ test results is critical to enable the development and evaluation of policy measures on how best to use the test. In this study, we set out to characterise Irish herds with IFN-γ test positive animals in terms of herd size, number of SICTT reactors and number of IFN-γ positive tests, and to evaluate the IFN-γ test in terms of the test cut-off values. The results showed that larger herds with more SICTT reactors were likely to have more IFN-γ positives in the herd, and herds with an IFN-γ test positive animal that was also positive for bTB lesions at post-mortem had higher numbers of IFN-γ positive animals in the herd. Raising the cut-off values for the IFN-γ test only marginally decreased the combined sensitivity of the IFN-γ and the SICTT for diagnosis of bTB lesioned animals. The analysis has provided valuable information on the performance of the IFN-γ test as it is used under current bTB infection levels in Ireland.
Collections Ireland -> University College Dublin -> Veterinary Medicine Research Collection
Ireland -> University College Dublin -> School of Veterinary Medicine
Ireland -> University College Dublin -> College of Health and Agricultural Sciences

Full list of authors on original publication

Eamonn Gormley, Simon John More, Eoin Ryan, Mairead B Doyle, Tracy A Clegg

Experts in our system

1
E Gormley
University College Dublin
Total Publications: 68
 
2
S J More
University College Dublin
Total Publications: 213
 
3
Mairead B Doyle
University College Dublin
Total Publications: 9
 
4
Tracy A Clegg
University College Dublin
Total Publications: 55