Type

Journal Article

Authors

Sinead M. Waters
Derek W Morris
Mark McGee
Clare Mckenna
Séan Coyle
Gordon Blackshields
Claire Fitzsimons
David A. Kenny
Marc G Higgins

Subjects

Veterinary

Topics
cattle feed immune response holstein friesian rna seq differentially expressed genes bovine genetics beef cattle feed efficiency

The effect of breed and diet type on the global transcriptome of hepatic tissue in beef cattle divergent for feed efficiency (2019)

Abstract Background Feed efficiency is an important economic and environmental trait in beef production, which can be measured in terms of residual feed intake (RFI). Cattle selected for low-RFI (feed efficient) have similar production levels but decreased feed intake, while also emitting less methane. RFI is difficult and expensive to measure and is not widely adopted in beef production systems. However, development of DNA-based biomarkers for RFI may facilitate its adoption in genomic-assisted breeding programmes. Cattle have been shown to re-rank in terms of RFI across diets and age, while also RFI varies by breed. Therefore, we used RNA-Seq technology to investigate the hepatic transcriptome of RFI-divergent Charolais (CH) and Holstein-Friesian (HF) steers across three dietary phases to identify genes and biological pathways associated with RFI regardless of diet or breed. Results Residual feed intake was measured during a high-concentrate phase, a zero-grazed grass phase and a final high-concentrate phase. In total, 322 and 33 differentially expressed genes (DEGs) were identified across all diets for CH and HF steers, respectively. Three genes, GADD45G, HP and MID1IP1, were differentially expressed in CH when both the high-concentrate zero-grazed grass diet were offered. Two canonical pathways were enriched across all diets for CH steers. These canonical pathways were related to immune function. Conclusions The absence of common differentially expressed genes across all dietary phases and breeds in this study supports previous reports of the re-ranking of animals in terms of RFI when offered differing diets over their lifetime. However, we have identified biological processes such as the immune response and lipid metabolism as potentially associated with RFI divergence emphasising the previously reported roles of these biological processes with respect to RFI.
Collections Ireland -> Teagasc -> Teagasc publications in Biomed Central
Ireland -> Teagasc -> Other Teagasc Research
Ireland -> Teagasc -> Livestock Systems
Ireland -> Teagasc -> Animal & Bioscience
Ireland -> Teagasc -> Animal & Grassland Research & Innovation Programme

Full list of authors on original publication

Sinead M. Waters, Derek W Morris, Mark McGee, Clare Mckenna, Séan Coyle, Gordon Blackshields, Claire Fitzsimons, David A. Kenny, Marc G Higgins

Experts in our system

1
Sinead M. Waters
Teagasc
Total Publications: 99
 
2
Derek Morris
Trinity College Dublin
Total Publications: 168
 
3
Mark McGee
Teagasc
Total Publications: 81
 
4
Clare Mckenna
Teagasc
Total Publications: 5
 
5
Gordon Blackshields
Teagasc
Total Publications: 19
 
6
D.A. Kenny
Teagasc
Total Publications: 147