Journal Article


Derek W Morris
Sinead M. Waters
Mark McGee
David A. Kenny
S.B. Conroy
Clare Mckenna
Matthew C. McClure
Clare Fitzsimons
Marc G Higgins


Agriculture & Food Science

beef cattle feed efficiency beef production single nucleotide polymorphisms cattle feed residual feed intake rfi quantitative trait loci genome wide association studies gwas

GWAS and eQTL analysis identifies a SNP associated with both residual feed intake and GFRA2 expression in beef cattle (2018)

Abstract Residual feed intake (RFI), a measure of feed efficiency, is an important economic and environmental trait in beef production. Selection of low RFI (feed efficient) cattle could maintain levels of production, while decreasing feed costs and methane emissions. However, RFI is a difficult and expensive trait to measure. Identification of single nucleotide polymorphisms (SNPs) associated with RFI may enable rapid, cost effective genomic selection of feed efficient cattle. Genome-wide association studies (GWAS) were conducted in multiple breeds followed by meta-analysis to identify genetic variants associated with RFI and component traits (average daily gain (ADG) and feed intake (FI)) in Irish beef cattle (n = 1492). Expression quantitative trait loci (eQTL) analysis was conducted to identify functional effects of GWAS-identified variants. Twenty-four SNPs were associated (P < 5 × 10−5) with RFI, ADG or FI. The variant rs43555985 exhibited strongest association for RFI (P = 8.28E-06). An eQTL was identified between this variant and GFRA2 (P = 0.0038) where the allele negatively correlated with RFI was associated with increased GFRA2 expression in liver. GFRA2 influences basal metabolic rates, suggesting a mechanism by which genetic variation may contribute to RFI. This study identified SNPs that may be useful both for genomic selection of RFI and for understanding the biology of feed efficiency.
Collections Ireland -> Teagasc -> Animal & Bioscience
Ireland -> Teagasc -> Animal & Grassland Research & Innovation Programme

Full list of authors on original publication

Derek W Morris, Sinead M. Waters, Mark McGee, David A. Kenny, S.B. Conroy, Clare Mckenna, Matthew C. McClure, Clare Fitzsimons, Marc G Higgins

Experts in our system

Derek Morris
Trinity College Dublin
Total Publications: 168
Sinead M. Waters
Total Publications: 99
Mark McGee
Total Publications: 81
D.A. Kenny
Total Publications: 147
S Conroy
Total Publications: 7
Clare Mckenna
Total Publications: 5