Type

Journal Article

Authors

Fionnuala M McAuliffe
P J Twomey
John Mehegan
Elizabeth Larkin
Mary K Horan
J A Riordan
Elizabeth O'Sullivan
Aisling A Geraghty
E C O'Brien

Subjects

Medicine & Nursing

Topics
nutrition follow up randomised control trial randomised controlled trial pregnancy maternal weight retention medicine and health sciences hba1c

Five-Year Follow Up of a Low Glycaemic Index Dietary Randomised Controlled Trial in Pregnancy—No Long-Term Maternal Effects of a Dietary Intervention (2019)

Abstract Objective: To determine whether a dietary intervention in pregnancy had a lasting effect on maternal outcomes of diet, HbA1c and weight retention 5 years post-intervention; and to establish whether modifiable maternal behaviours were associated with these outcomes. Design: Randomised control trial of low glycaemic index (GI) diet in pregnancy with longitudinal follow up to 5 years post-intervention. Setting: Dublin, Ireland (2007–2016). Population: In all, 403 women of 759 (53.1%) were followed up at 5 years. A total of 370 (intervention n = 188; control n = 182) were included in this analysis. Methods: Fasting glucose was measured at 13 and 28 weeks’ gestation and HbA1c (mmol/mol) at 5-year follow up. Weight retention (kg) from early pregnancy to 5 years post-intervention was calculated. Dietary intakes, anthropometry, and lifestyle factors were measured in pregnancy and 5 years post-intervention. Multiple linear regression models, controlling for confounders, were used for analysis. Outcome: Maternal diet, HbA1c, and weight retention at 5 years post-intervention. Results: There was no difference between the intervention and control at 5 years post-intervention for any long-term maternal outcomes measured. HbA1c at 5 years post-intervention was associated with early-pregnancy fasting glucose (B 1.70, 95% CI 0.36–3.04) and parity ≥3 (B 1.04, 95% CI 0.09–1.99). Weight retention was associated with change in well-being from pregnancy to 5 years (B −0.06, 95% CI −0.11 to −0.02), gestational weight gain (B 0.19, 95% CI 0.00–0.38), and GI (B 0.26, 95% CI 0.06–0.46) at 5 years. Conclusions: The ROLO low-GI dietary intervention in pregnancy had no impact on maternal dietary intakes, HbA1c or body composition 5 years post-intervention. Maternal factors and lifestyle behaviours in pregnancy have long-term effects on glucose metabolism and weight retention up to 5 years later. Tweetable abstract: Pregnancy factors are associated with maternal glucose metabolism and weight retention 5 years later.
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Full list of authors on original publication

Fionnuala M McAuliffe, P J Twomey, John Mehegan, Elizabeth Larkin, Mary K Horan, J A Riordan, Elizabeth O'Sullivan, Aisling A Geraghty, E C O'Brien

Experts in our system

1
Fionnuala M McAuliffe
University College Dublin
Total Publications: 176
 
2
John Mehegan
University College Dublin
Total Publications: 13
 
3
Mary K Horan
University College Dublin
Total Publications: 11
 
4
Aisling A Geraghty
University College Dublin
 
5
Eileen C O'Brien
University College Dublin