Type

Other / n/a

Authors

Noel G McElvaney
Noreen Lacey
Kerstin Pohl
Danielle M Dunlea
Michelle M White
Maya Sakthi N Vijayan
Oliver J McElvaney
Cormac McCarthy
Emer P Reeves

Subjects

Medicine & Nursing

Topics
medicine and health sciences anti inflammatory this review down regulation hypertonic saline neutrophils and inflammation mucociliary clearance cystic fibrosis

Inhaled hypertonic saline for cystic fibrosis: reviewing the potential evidence for modulation of neutrophil signalling and function. (2016)

Abstract Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The major cause of mortality and morbidity is lung disease with increasing pulmonary exacerbations and decline in lung function predicting significantly poorer outcomes. The pathogenesis of lung disease in CF is characterised in part by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. This leads to accumulation of viscous mucus in the CF airway, providing an ideal environment for bacterial pathogens to grow and colonise, propagating airway inflammation in CF. The use of nebulised hypertonic saline (HTS) treatments has been shown to improve mucus clearance in CF and impact positively upon exacerbations, quality of life, and lung function. Several mechanisms of HTS likely improve outcome, resulting in clinically relevant enhancement in disease parameters related to increase in mucociliary clearance. There is increasing evidence to suggest that HTS is also beneficial through its anti-inflammatory properties and its ability to reduce bacterial activity and biofilm formation. This review will first describe the use of HTS in treatment of CF focusing on its efficacy and tolerability. The emphasis will then change to the potential benefits of aerosolized HTS for the attenuation of receptor mediated neutrophil functions, including down-regulation of oxidative burst activity, adhesion molecule expression, and the suppression of neutrophil degranulation of proteolytic enzymes.
Collections Ireland -> Royal College of Surgeons in Ireland -> Medicine Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Medicine

Full list of authors on original publication

Noel G McElvaney, Noreen Lacey, Kerstin Pohl, Danielle M Dunlea, Michelle M White, Maya Sakthi N Vijayan, Oliver J McElvaney, Cormac McCarthy, Emer P Reeves

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
Noreen Lacey
Royal College of Surgeons in Ireland
Total Publications: 4
 
3
Kerstin Pohl
Royal College of Surgeons in Ireland
 
4
Danielle M Dunlea
Royal College of Surgeons in Ireland
Total Publications: 6
 
5
Michelle M White
Royal College of Surgeons in Ireland
Total Publications: 10
 
6
Oliver J McElvaney
Royal College of Surgeons in Ireland
 
7
Cormac McCarthy
Royal College of Surgeons in Ireland
Total Publications: 19
 
8
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63