Type

Other / n/a

Authors

Tobias Engel
Catherine Mooney
Elena Langa
Amaya Sanz-Rodriguez
Eva Jimenez-Mateos
Claire Mooney
Caroline Sheedy

Subjects

Biochemistry

Topics
epilepsy myelin basic protein chop physics physiology gene expression mrna microarray status epilepticus

De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP. (2014)

Abstract The C/EBP homologous protein CHOP is normally present at low levels in cells but increases rapidly after insults such as DNA damage or endoplasmatic reticulum stress where it contributes to cellular homeostasis and apoptosis. By forming heterodimers with other transcription factors, CHOP can either act as a dominant-negative regulator of gene expression or to induce the expression of target genes. Recent work demonstrated that seizure-induced hippocampal damage is significantly worse in mice lacking CHOP and these animals go on to develop an aggravated epileptic phenotype. To identify novel CHOP-controlled target genes which potentially influence the epileptic phenotype, we performed a bioinformatics analysis of tissue microarrays from chop-deficient mice after prolonged seizures. GO analysis revealed genes associated with biological membranes were prominent among those in the chop-deficient array dataset and we identified myelin-associated genes to be particularly de-repressed. These data suggest CHOP might act as an inhibitor of myelin-associated processes in the brain and could be targeted to influence axonal regeneration or reorganisation.
Collections Ireland -> Royal College of Surgeons in Ireland -> Physiology and Medical Physics Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Physiology and Medical Physics

Full list of authors on original publication

Tobias Engel, Catherine Mooney, Elena Langa, Amaya Sanz-Rodriguez, Eva Jimenez-Mateos, Claire Mooney, Caroline Sheedy

Experts in our system

1
Tobias Engel
Royal College of Surgeons in Ireland
Total Publications: 66
 
2
Catherine Mooney
University College Dublin
Total Publications: 63
 
3
Elena Langa
Royal College of Surgeons in Ireland
Total Publications: 5
 
4
Amaya Sanz-Rodriguez
Royal College of Surgeons in Ireland
Total Publications: 18
 
5
Eva M Jimenez-Mateos
Royal College of Surgeons in Ireland
Total Publications: 55
 
6
Claire Mooney
Royal College of Surgeons in Ireland
Total Publications: 8