Type

Other / n/a

Authors

Martin Clynes
Paul Dowling
Paul Neary
Pavel Vodicka
Miroslav Levy
Alessio Naccarati
Barbara Pardini
David J Hughes
Stephen F Madden
Sinéad T Aherne

Subjects

Psychiatry

Topics
mir 34a mir 150 physiology circulating mirnas mir 923 physics colorectal cancer early detection

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. (2015)

Abstract BACKGROUND: Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups.METHODS: The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues.RESULTS: High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In addition, the altered expression of miR-34a and miR-150 in an independent public dataset of forty CRC samples and paired normal tissues was confirmed.CONCLUSION: We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups.
Collections Ireland -> Royal College of Surgeons in Ireland -> Physiology and Medical Physics Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Physiology and Medical Physics

Full list of authors on original publication

Martin Clynes, Paul Dowling, Paul Neary, Pavel Vodicka, Miroslav Levy, Alessio Naccarati, Barbara Pardini, David J Hughes, Stephen F Madden, Sinéad T Aherne

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Paul Dowling
Dublin City University
Total Publications: 79
 
3
Paul C Neary
IT Tallaght
Total Publications: 62
 
4
Pavel Vodicka
Royal College of Surgeons in Ireland
Total Publications: 4
 
5
Alessio Naccarati
Royal College of Surgeons in Ireland
Total Publications: 6
 
6
David J Hughes
Royal College of Surgeons in Ireland
Total Publications: 20
 
7
Stephen F Madden
Dublin City University
Total Publications: 42
 
8
Sinéad T Aherne
Dublin City University
Total Publications: 17