Type

Other / n/a

Authors

David C Henshall
Miguel Diaz-Hernandez
Maria Teresa Miras-Portugal
Alba Jimenez-Pacheco
Tobias Engel

Subjects

Psychiatry

Topics
physics physiology this review anticonvulsant epilepsy hippocampal sclerosis interleukin 1 beta adenosine 5 triphosphate stats epilepticus

P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. (2012)

Abstract The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has also been linked to microglia activation and neuroinflammatory responses. Accordingly, interest developed on the P2X7 receptor in disorders of the nervous system, including epilepsy. Studies show that expression of the P2X7 receptor is elevated in damaged regions of the brain after prolonged seizures (status epilepticus) in both neurons and glia. P2X7 receptor expression is also increased in the hippocampus in experimental epilepsy. Recent data show that mice lacking the P2X7 receptor display altered susceptibility to status epilepticus and that drugs targeting the P2X7 receptor have potent anticonvulsant effects. Together, this suggests that P2X7 receptor ligands may be useful adjunctive treatments for refractory status epilepticus or perhaps pharmacoresistant epilepsy. This review summarizes the evidence of P2X7 receptor involvement in the pathophysiology of epilepsy and the potential of drugs targeting this receptor for seizure control.
Collections Ireland -> Royal College of Surgeons in Ireland -> Physiology and Medical Physics Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Physiology and Medical Physics

Full list of authors on original publication

David C Henshall, Miguel Diaz-Hernandez, Maria Teresa Miras-Portugal, Alba Jimenez-Pacheco, Tobias Engel

Experts in our system

1
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127
 
2
Miguel Diaz-Hernandez
Royal College of Surgeons in Ireland
Total Publications: 13
 
3
M Teresa Miras-Portugal
Royal College of Surgeons in Ireland
Total Publications: 12
 
4
Alba Jimenez-Pacheco
Royal College of Surgeons in Ireland
Total Publications: 10
 
5
Tobias Engel
Royal College of Surgeons in Ireland
Total Publications: 66