Type

Other / n/a

Authors

Tobias Engel
M Teresa Miras-Portugal
Miguel Diaz-Hernandez
David C Henshall

Subjects

Psychiatry

Topics
physiology interleukin 1 physics epilepsy neuroprotection atp anticonvulsant microglia hippocampus

P2X receptors as targets for the treatment of status epilepticus. (2013)

Abstract Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage. Frontline treatment comprises parenteral administration of anticonvulsants such as lorazepam that facilitate γ-amino butyric acid (GABA) transmission. Because status epilepticus can become refractory to anticonvulsants in a significant proportion of patients, drugs which act on different neurotransmitter systems may represent potential adjunctive treatments. P2X receptors are a class of ligand-gated ion channel activated by ATP that contributes to neuro- and glio-transmission. P2X receptors are expressed by both neurons and glia in various brain regions, including the hippocampus. Electrophysiology, pharmacology and genetic studies suggest certain P2X receptors are activated during pathologic brain activity. Expression of several members of the family including P2X2, P2X4, and P2X7 receptors has been reported to be altered in the hippocampus following status epilepticus. Recent studies have shown that ligands of the P2X7 receptor can have potent effects on seizure severity during status epilepticus and mice lacking this receptor display altered seizures in response to chemoconvulsants. Antagonists of the P2X7 receptor also modulate neuronal death, microglial responses and neuroinflammatory signaling. Recent work also found altered neuronal injury and inflammation after status epilepticus in mice lacking the P2X4 receptor. In summary, members of the P2X receptor family may serve important roles in the pathophysiology of status epilepticus and represent novel targets for seizure control and neuroprotection.
Collections Ireland -> Royal College of Surgeons in Ireland -> Physiology and Medical Physics Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Physiology and Medical Physics

Full list of authors on original publication

Tobias Engel, M Teresa Miras-Portugal, Miguel Diaz-Hernandez, David C Henshall

Experts in our system

1
Tobias Engel
Royal College of Surgeons in Ireland
Total Publications: 66
 
2
M Teresa Miras-Portugal
Royal College of Surgeons in Ireland
Total Publications: 12
 
3
Miguel Diaz-Hernandez
Royal College of Surgeons in Ireland
Total Publications: 13
 
4
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127