Type

Other / n/a

Authors

Patrick J Prendergast
Fergal J O'Brien
Magnus Tägil
Sara Checa
Hanifeh Khayyeri

Subjects

Biochemistry

Topics
cell culture techniques biological tissue engineering osteoblasts chondrocytes bioreactors anatomy cell differentiation hardness tests fibroblasts humans hardness models biological osteogenesis animals rats bone and bones tissue scaffolds computer simulation

Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness. (2010)

Abstract Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a lattice approach is very suitable for modelling scaffolds in mechano-biological simulations, since it can accurately represent the micro-porous geometries of scaffolds in a 3D environment and reduce computational costs at the same time.
Collections Ireland -> Royal College of Surgeons in Ireland -> Anatomy Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Anatomy

Full list of authors on original publication

Patrick J Prendergast, Fergal J O'Brien, Magnus Tägil, Sara Checa, Hanifeh Khayyeri

Experts in our system

1
Patrick John Prendergast
Trinity College Dublin
Total Publications: 80
 
2
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268